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4.5 Alzheimer’s disease Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders induced by chronic neuroinflammation with increased activation of microglia and astrocytes, leading to cognitive impairment and dementia (213, 214)

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The apparent t 1/2 values of 50 and 120 seconds for DMPO/ • SG and DEPMPO/ • SG were in good agreement with previous studies 29,30,32 , and the decay of EBN/ • SG and DEPMPO/ • SG exhibited similar kinetic profiles